Renting RV with driver for overnight sleeping trips

Just guessing but that set up would make the hired driver a "professional" and subject to limited hours driving. Your estimate of 500 miles a night means 10 hours of driving. That would probably mean the driver would have to take naps and keep a log. Maybe two drivers? Husband and wife team? Now things get complicated and expensive. I'd be worried about the driver getting sleepy and I wouldn't be able to sleep. May as well fly to each destination and hotel it.