I am not going to offer an opinion of my own, but this came up at an FMCA talk at one of the rallies in a session with Roger Marbles.
As several said up thread, the best way to repair an otherwise good tire is to do a minimum plug to keep environment out of the steel cord area and then do an internal patch for the air seal.
Yes, you can plug tires on agricultural machines, but they are not highway tires. They are a different animal. What did love was the way that they plugged the damage to a mine-haul truck (about 12' tall and 4'wide). A guy came from the maintenance shop with a cryo-bottle. He pulled a giant lag screw out of the boiling cryo-bottle and used a large air wrench to screw it into the puncture. The crew waited a little while and then sawed off the extra of the plug and put air back in the tire.
Matt