Assuming a toad and similar fancy gadgets (ie: generators, leveling systems , etc..)it's roughly the same amount of time to set up or break camp.
You can go to the bathroom while driving with a MH but as a full timer, you don't have to do 20hr drives. We shoot for 2-3hrs and if we need to stop we can always walk the "massive" distance back 20ft and use the bathroom we are towing.
Setting up in the rain likewise isn't a big difference. As full timers, we don't typically have to travel in bad weather. But even if we do get caught in it, you can just open the slides and wait it out in comfort, so not a big deal.
Fuel economy with the toad is not so great when you look big picture. MH's typically get 4-6mpg while trailers typically get 8-12mpg, so it's going to take a lot of miles on the toad to cancel out the extra fuel when the RV is moving.
Cost is where the TT/5th wheel shines. For equivalent units a MH is typically far more expensive.