If you have a new model F350, you should have both Tow/Haul function and Engine Braking. I pull a 16k lb 5ver with a 2016 F350 DRW. I will pull most grades at 65mph unless I (unintentionally) get behind a slow moving vehicle.
I will usually start any significant grade selecting 5th (but still in cruise), to attempt quicker converter lockup. (At this point I am unsure if the converter locks in 5th or 4th on the 2016 transmission). It is rare that I will see an automatic downshift into 4th.
For descent, I will set my cruise at 55mph, and the combination of tow/haul and exhaust brake always holds me to within 5 mph (sometimes climbing to 60 prior to applying increased hold back) of 55mph.