Depends a lot on where you plan to go camping or where you live.
We have 4WD in our F250. Have never used it and likely never will as we almost never get snow in the SW corner of BC and we only camp in "civilized" CGs with full hookups. The added weight means less payload capacity. 4WD is also a few inches higher off the ground (5-6"?) - harder to access the bed and harder to get in & out (at least for us).