The difference between a 2wd F150 I looked at and the same exact optioned 4wd truck was #130.. The 2wd had a #2050 payload sticker and the 4wd has #1920 payload sticker.
I got the 4wd and paid more for it too! But, that's because I wanted a 4wd truck.. Not so much for 'towing', but for overall general use of the truck and it sure is nice to have that 4lo to park the trailer at home.
So, it's gonna be an individual thing as to the pros/cons..
Good luck!
Mitch