I cannot think of a single reason to use two 12 vs 2 6's.
The Marine batts, as stated, are a compromise. Intended for a boat. Boaters use the same battery to start the motor (need lots of amps all at once) and to run the trolling motor (need small amt of amps over a long period), and then be able to start the boat engine again.
The thick plates of a true deep cycle battery cannot give the sudden burst of amps as the thin plates of a car starting battery. A Deep Cyc batt may not be able to start an engine.
The thin plates of a car batt cannot be run dead many times at all before ruin - you can count this on one hand...
Marine is a compromise, so has medium thickness plates. You can run them dead (certain percentage of state of discharge) more than a car bat, but not as many times as a true deep cyc batt.
I dont have the exact numbers but something like this:
car batt can be run dead 2 times
marine batt can be run dead 200 times
true deep cyc batt can be run dead 2,000 times.
(do a search if you want to real numbers on this, but the disparity is similar)
This is the reason for true deep cycle batts.