The short answer, IMO, is yes to some degree. Different chassis ride differently. Among DP even though they all use airbag suspension there are different manufactures and they all seem to do things a little different which changes the right to different extends. A class A will ride different than a class C.
Quality of materials and the way they are screwed together in the house part of motorhome makes a difference too.
It would be best for you and your wife to just go out and drive different motorhomes. That will give you a prospective on what to expect in motorhome travel.
Good Luck and good hunting.
Paul