Here's a little different perspective... We're full-timers, and in a fifth wheel rather than a motorhome. When we hit the road, we knew we didn't want to use a crew cab diesel truck (our current truck is a long bed dual rear wheel, to boot) as a daily driver. We had a Toyota sedan at the time and the advice from the folks on the Escapees forum was to try the "chase car" for a year or so. If we didn't like it, we could reconfigure. Turns out, we like it a lot. My wife doesn't mind driving on travel days. She gets to listen to her audio books and music whenever she likes (I don't like anything on in the cab in heavy traffic or big cities). She can keep the thermostat up where she likes it, etc.
We average about 12K miles/year with the rig but put another 6k - 8K on the car touring, sightseeing, shopping, or running back and forth between wherever we're staying and kids/grandkids/siblings/parents houses. We typically do not travel more than 150 miles per day on travel days, so it's not that much time apart. We sold the Toyota and bought a Honda CR-V last spring and we're still very happy with the the "chase car" approach.
We have a document with the pros and cons from our POV - but it's aimed at full-timers in towables. If you're interested in that document, let me know.
Rob