We have the V10 in our 250. It is awesome. Plenty of power & torque and it feels so smooth with the extra 2 cylinders. If you are going to be towing in hilly areas a lot, I'd definitely get a V10 if you can. We wanted the V10 along with super cab and 8' box. Very hard to find (at least in our area). It came with 4WD and we never use it - waste of money plus it reduces payload capacity.
Also have 4.10 gears and tow/haul. First time having a truck with T/H and would never go without it now for towing. Great for long level stretches.