My first summer living in my RV was in South Carolina. I got bit by spiders inside my RV twice (one bite turned black and purple like a bad bruise, was kinda scary), and also had several fire ant colonies in my site and got bit by those multiple times (red swollen pustules, still have some scars). Do the sensible thing and if your going to camp in the southeast for any length of time, do so in the winter when colder temperatures hold the multitudes of insects in check. :P
On the other hand, when I first arrived at Badlands National Park this spring a herd of mule deer would frequently travel through the campground, they'd get quite close and it was neat. When I was at Mt. Rushmore two days ago a mountain goat was mowing down grass not 15 feet from the trail, also cool. I also got to see a coyote driving home from my work camping job one night, waiting to cross the road.