It is not an issue with an SRW truck 99.98% of the time.
Old villages can be a challenge.
Small backroads, too.
And campground access roads due to height and width - because strangely, many are so overgrown that you wonder how the other rigs got there in the first place.
Downtown traffic is harmless since the roads are used by trucks all the time. Parking garages are out, anyway.
I can not speak for all european countries, obviously.
Probably the biggest "issues" are low old railroad bridges or underpasses that you failed to see in time, and now you must backtrack and find another route. Specialized GPS systems for trucks and RVs exist that should help you avoid these.
But you must realize that technical support is pretty thin for these trucks. Not many shops can work at them. Get good roadside assistance in case you need to be towed. Ensure in the contract that they realize the dimensions of your rig. Most here exclude anything above 3.20m height.
Nobody will probably touch your camper if something needs to be fixed. At least that is my personal experience. You are probably used to do most repairs yourself anyway ;-)
