I haven't set up my CRV as toad but did some research before I bought. Removing fuse isn't designed to protect the radio but save you from depleting the battery - all the radio/electronic stuff runs though that fuse. Apparently after towing a long distance dead batteries are common problem. Removing fuse is suppose to resolve the problem but accessing the fuse is PIA - some put in switch - others run a charge wire from rig to toad battery.
I know my 2014 came with an undersized battery - and lots of complaints about people being stranded. I got stranded by leaving my lights radio on waiting for my wife to finish shopping - so I have no doubt that long distance tow might result in dead battery.
