You are right, I have never had a fifth wheel. But I do stay at rv parks about 100 days a year and have watched lots of folks set up. A motor home is simpler, the rigid truck frame permits not putting down the auto jack on days you wish to keep it really simple. When your are by yourself, backing and maneuvering a large trailer is more complex also.
For my fishing vehicles I tow a small 4 wheel drive pickup.
Since your questions indicate you are just starting out, consider renting a class C for a couple of weeks. Your experience level will soar and help you make the right decision
pops