We traveled many miles in a 30' class A with a large Standard Poodle(50+ pounds) and a large show sized Greyhound( 85+ pounds of greased snake) and had many adventures of all kinds. Things to think about include big strong jaws with lots of big teeth, need to carry and use lots of big poop bags, Idiots with other dogs that run up too close with little yippy pets, Kids with stupid parents that let their kids run to to big doggies, need and ability to get out and exercise bigger dogs, the amount of food required for bigger dogs, and just the sheer space requirements for a bigger dog. Also consider the general public opinion of the breed you are considering. And never forget the actual character of the breed. A greyhound was bred to be a fast efficient killer of small fast game, be it a wild rabbit or a loved small cat or dog. A poodle was and are, very efficient water retrievers of dead things. A full sized, standard poodle with a bad attitude and attack training is something you don't want to be on the bad side of. Our greyhounds attitude was "love Everybody" and the poodle was "everybody loves ME"