I just returned from Puerto Vallarta and we took a trip a few months ago to Cabo San Lucas. Neither with the rig, but Mexico is definitely disability friendly and the ADA rules apply when they can. Even in some of the smaller towns we visited ramps were available for our disability scooter...not many ramps but enough. Roads are rough, rocky, and sometimes unpaved, making travel with a wheelchair or scooter challenging, but not impossible. People were extremely friendly, and helpful. Coming to a corning where my wife would have to get out of the scooter so I could lift the thing to the next level shop owners or others would always offer to assist. There are may second story shops and restaurants that do not have access other than steps. But all in all, we had a wonderful trip/vacation. Personally, I am still afraid to take the MH down south, wish I were not, as we used to go that way often, and we had a fantastic trip with TRACKS years ago over the mountain on the train. But that is another story and my paranoia. But as for your trip, I would have little or no concern. Travel Safe, and Happy Trails.