I own two Mr Heater, One of them, the portable, I had used in my old trailer (and boat while fishing). I used the small Coleman bottles, but I refilled them as needed. I would keep one in the freezer while using one. When I ran out of fuel, I would charge the bottle us by using the adapter which is available and a small tank of propane, like a 5 pound bottle.
I got the Big Buddy for the new trailer and had the dealer put in a quick connect to the larger propane bottles in the trailer. I bought the 12 foot hose which has a quick connect on one end and the female 3/8 female flare on the other. I had to reduce the 3/8 in to a 1/4 in. It works well. I have only used it once so far, but it does the job without opening windows.
The thing is, I don't go to sleep at night with it on, but that is me.