I’ve been on them forever. My psoriasis is not very widespread but on the feet and will cause cracks and splits...making walking very difficult or impossible w/o them. Also have psoriatic arthritis. I’ve had no side effects but do tend to easily catch colds and upper respiratory ailments (2 to 3 times a year). My Humira is not working as well as it used to so my rheumatologist is switching me to Taltz. It’s “supposed” to work better on the psoriasis and not suppress the immune system as much.