I've found myself having to go thru major towns MH towing and during rush hour and really it's not that big of a deal. I hang in the right lane and just plod along.
If you don't want a death grip ride thru a major city just plan your trips to go thru late at night after 10 or so, I find that the most enjoyable way to go thru a major city.
OR if you plans don't allow that, just make sure to avoid rush hour times. Even if means hanging out at a rest area for a few hours till it's over and then get on the road.
I plan most of my trips where I plan to stay at a CG just outside the major city, relax and enjoy the evening and then I get up around 4:00 and cruise right thru the town. KOA just outside Atlanta is my routine stop for the night when heading south for the winter.