Seems to be two different conversations going on here. Some are talking about driving on a highway/interstate through a city, others are talking about driving in the middle of a city off the highway.
Highway through a city - no big deal, just pay attention to traffic, try to stay in middle lane if there is one. If a car is coming up an entrance ramp and you can't move over or brake, the car has to yield. Happened to me once in a big way - a guy in a Lincoln, who obviously was very important and was going somewhere very important, came screaming up an on ramp while we were in packed rush hour traffic. I simply could not move over or brake or speed up - he came within inches of my truck before he slowed down to look for a break in traffic. It was close, but it worked out, if I had tried to "avoid" him I probably would have caused a multi car accident (technically it would have been his fault, but try explaining that).
Driving through city streets - I avoid that when at all possible. Sometimes you just have to bull your way through, like city buses do. Also think of your out of state license plate as the "dumb tourist pass" and just go. And ignore, or wave back, at those saying you are number one (usually they use the wrong finger, though...).