Three or four shots of Jim Bean seem to help.
Seriously, I try to avoid big cities if at all possible whether I am pulling or just in a car. Most large cities have a loop around. Of course often that is of no help because every one else is on the loop to avoid the city. I often find no choice and have driven in many big cities. I think Kansas City must have been planed by some evil sadist. Time and again lanes end with only about 50 foot warning. I think the worst ever was driving with my 30 foot TT through downtown Chicago. I have since been told that it is not allowed. It is not really that horrible, except because of never ending construction don't even try I-35W north of Fort Worth except possibly between 2 and 4 in the morning, just slow down, plan ahead and shut your eyes tight.