some great reading on this discussion........BenK, love your advice based on experience
my TV is a '13 F450, so 4WD only option
Also home base is Alaska, so 4WD pretty much a no brainer, although our 2nd vehicle for many years was a front 2WD sedan and it did amazing well if you understood how to drive it.
Don't have a lot of experience towing the 5er yet, but 45+ years of driving in winter and on less than optimum summer roads taught me that 4WD is best used to get OUT of situations you shouldn't have got IN with 2WD.