Yup, here's my process: Clean with Jasco Prepaint conditioner (TSP substitute), fill any holes or other, sand, rinse. Scuff with 3M pads, rinse. Prime with DTM primer, caulk seams, prime back over caulk. Paint with a good quality acrylic latex paint. Paint accent colors. I have an airless sprayer and masking equipment.
Before:
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After:
More pics in the build thread in my sig line, "The Cowboy/Hilton"