We rented a "Standard" motor home from Cruise America in Everett WA last summer and it was a great experience. Their "standard" is a Class C about 24-25' in length. It was big enough to give the 3 of us all the room we needed, yet still small enough to use it for daily transportation. We did miss a lot of the things we normally have with us when camping like the Coleman stove for cooking outside and fire tools for example. The thing we missed the most was not having our bicycles with us.
So yes, there are trade offs, but for us driving across the country was out of the question. And as I said, it was a great experience.
Be forewarned though, as fellow pop-up owners, after renting the MH, you may find yourself in the market for something bigger. We will be trading in the pup for a TT in the next month or so!