Tire Wear

I would not reverse the tire until I had an alignment done after the bearings and spindle situation are corrected. A commercial vehicle shop can align the axles but seeing that tire wear would be helpful.

how many miles are on that tire in that location, and how many miles are on that tire? 

 The first thing I would do is rotate a different tire that looks good into that location and see if it does the same thing, that way you can check it at a frequent intervals.  To me it looks like it could be an alignment issue but it could also be a tire issue.  I had one that did the exact same thing, replaced it as I also found a broken beed on the tire (which I also see on yours)  and it has been perfect since then.

last photo of spindle, shows signs of the bearing inner sleeve spinning on spindle.  Use a a caliper o see if spindle is out of round.  Check bearing for roundness.

Well now you know why the previous owner sold the trailer. There is something very wrong with that axel. You have burned baring's, and a tire that looks like it locked up and dragged.

I would take it to a good RV dealer to have it checked out. 

I would not replace the tire right away. Have it reversed on the rim.

Make sure whoever does the bearing replacement checks the spindle.

Keep us informed of your progress.

Here’s my thoughts after using and or repairing a lot of light duty trailers over the years. 
Yes, looks like the bearing spun, no, doesn’t look like a big deal unless it’s worn the spindle down too much. Slap a new bearing on it when you put it back together and check it again in a few thousand miles. Provided the bearing isn’t obviously loose on the spindle. 
This, I’m relatively confident has nothing to do with the tire wear. 
And being it’s only one tire and you see a 1/4” misalignment it’s a bent spindle or axle. 99% certain. 
Next question is how many miles do you plan on putting on it?  If you believe the PO and that’s 5k miles of wear, and you’ll only be putting 1-2k miles a year on it, I personally wouldn’t do anything except replace all tires at whatever interval you like and worst case flip that bad tire once or rotate it to another position every year or so. 
Now if you’re traveling x country every year and packing on thousands of miles per year, I’d personally fix the issue because you’ll be dealing with it more often otherwise. 
Not uncommon for front axles to get bent more often as they hit the bumps and holes first. Just like the most common blown tire is aft passenger side. 

If those GYs are still good and you’re gonna run them this year I’d just rotate that tire to another spot and hit the road.