Be wary on dry weights of Sprees. Our 262RKS has a tongue wt. of around 14.5 percent and actual total wt. is a couple hundred lbs away from it's GVWR. You could very well have a tongue wt. well in excess of the receiver rating. You'll probably need to upgrade the receiver anyway as the WDH required bar rating may necessitate that.
Good choice on the F250. Ours has 4.10 gears and love it. If you aren't towing in a lot of hills, you may not need that low but it will definitely accelerate better. 2WD is a good idea. 4WD is costlier to buy and maintain, reduces payload cap. and is about 1/2 foor higher off the ground. If you get a long bed and super or crew cab, the longer wheelbase will help with a TT that long.