I can't address your health issue part, but I can say that a motorhome is definitely "easier" to set up than a trailer as long as you aren't towing a toad. With a toad, you will still have to do the hitching, etc. In addition, you may need to unhitch and drive both into a campground/park separately.
For comfort, I recommend you drive several and see. When my dad had his prostate surgery and came home with a temporary bag, he had a difficult time with having to climb up into a truck or bending down to get into a car. He found my Dakota (and then Durango) to be a perfect seat height for getting in, and they didn't have that lip that jeeps do (he always stubbed his feet on that lip). Just something to consider.
Hope they knock that cancer senseless.
