The entire coast is breathtaking (especially from a "Florida" perspective) - but the stretch from Florence, north past Yachats, is amazing. Plan on lots of time spent simply looking/photographing. Probably one of our favorite camping places was Ft Stevens State Park, at the mouth of the Columbia River. Each campsite is tucked into a forest of massive trees.
Gold Beach was a great little waterfront town - look for the wreck of the Mary D Hume in the harbor. The bridges of Oregon are spectacular - very Gothic or Art Deco in design. I'll be honest, when we were there 2 years ago in the fall, many of the waterfalls had been reduced to trickles due to drought, so I can't really comment on those.
Hood River and the Columbia Gorge are amazing - we were treated to about a hundred kitesurfers/sailboarders out enjoying the river and wind!