Easily enough.
I work in IT and support folks in the Minneapolis area. But short of fixing a printer, or deploying a computer (physically putting it in place) I can remotely fix most issues, so I *could* work from anywhere if our manager allowed it. However I use multiple monitors when I'm in the office.
My wife is a software trainer and has 25 years of experience in wholesale inventory software. She can use a voice-over-ip phone and a laptop, although working from home is easier as she has more space to use multiple monitors.
Once I finish some more training in the next couple of years I will be able to work from anywhere - although the speed of the internet could make it interesting if we're both hogging bandwidth.
edit: forgot to add, I also administer a campground website on a volunteer basis (am trying to get them to pay me, but it's a non-profit). My wife also helps a friend of ours with their website and it may be a paying job soon.
You could support websites pretty easily on the road.