I had my rear drums changed on my 1975 pickup (back in 92 when it was only 17 years old) and they did not tell me to tighten the lug nuts every 100 miles for the first few weeks, while the new lug studs where 'set' into place. So my drivers side rear tire came off while I was doing 55 on the freeway, with a camper on the back of the pickup.
It was more a in-convience than a 'scary situation'. Lucky for me, someone stopped and noticed where my rear tire went to, and actually went and brought it back to me. I had to be towed to town, where they installed 8 new lugs on the drivers side, and I tightened the passenger side lugs all the way there.
I have had a couple of blow out tires on the rear of my motorhome, more an in-convience thing too. I changed the tires myself, rather than wait for AAA to show up. It did not really shake the RV or anything.
I probably would recommend a small class C, rather than a truck and trailer. Look into the cost of both ways, and I think that the motorhome way is much easier. I can park just about anyplace on the way to a destination, such as a church parking lot, or in front of a school.
My class C had twin beds in the back, and I changed that to a king size bed by moving the cabinets around. It had a split bath, and dinette on the drivers side just behind the driver. You can put the kids seats facing forward or backward on the dinette. Many are laid out this way.
Good luck,
Fred.
