I copied this straight from the EPA's FAQ.
What Vehicles May Use E15?
•Flexible-fuel vehicles (FFVs)
•MY2001 and newer cars
•MY2001 and newer light-duty trucks
•MY2001 and newer medium-duty passenger vehicles (SUVs)
What Vehicles and Engines May Not Use E15?
•All motorcycles
•All vehicles with heavy-duty engines, such as school buses, transit buses, and delivery trucks
•All off-road vehicles, such as boats and snowmobiles
•All engines in off-road equipment, such as lawnmowers and chain saws
•All MY2000 and older cars, light-duty trucks, and medium-duty passenger vehicles (SUVs)