I have sleep numbers in the house and both rv's.
I can tell you that the sleep number beds for the home have 3 or 4 different levels of toppers.. from fairly thin (similar to what comes on the rv bed) to if I remember right even a memory foam topper.
The RV model I have the topper is not as thick as the one at the house.. but it adjusts just the same. My RV bed only has one remote but that hasn't been a problem.. the one at home only had one remote also but I opted for a 2nd remote. The air pump seems smaller on the RV model but works well.
Remember that if you travel from low altitude to a higher altitude to let some air out of the bed before you travel...
Also the pump is 110v only.. so boon-docking can be a problem if you need to adjust your pressure without a 110v hookup.. I have to just run the genny for a few mins if I need to adjust the pressure.