Tow rating should not be your primary concern, as strange as that sounds. Either truck will "pull" the RV basically the same. Any fifth wheel has a good bit of pin weight on the truck. Think up to about 20%. So, the question is not will the F250 pull it but will it support the pin weight of the trailer you intend to buy?
It's entirely possible that an F250 would pull it fine but require tire, wheel, and spring upgrades to properly carry the pin weight.
Pick out the trailer. Find out it's fully loaded pin weight. Then, get a truck that has that much payload capacity plus capacity for any people and gear you will add to the truck.
I bet you'll find you need a dually.
I've daily driven one for 8 years now. It's no big deal.
