It's comforting to know that the more things change, the more they stay the same. Same tired old BS answers... Need it if you have it, but want it if you eat it. Whatever.
The simple fact of the matter is the market is going to 4x4. 2WD is going the way of the manual transmission; more expensive to keep the option in the inventory vs. the number of units sold. I would bet in 10 years you won't be able to buy a 2WD pickup truck of any description.
IMHO you will be able to find a better deal on a 4x4. It might actually end up being CHEAPER than the 2WD simply based on how rare 2WD trucks are. Dealers will be less willing to cut you a deal on the 2WD because they know there is a small but passionate market who are foolishly willing to pay more for less. If you're not fool enough to pay full retail, someone else will.
Overall you will get a better value for your money on the 4x4 even if you spend a little more.
The 4x4 technology these days is so refined that it doesn't really hurt your fuel economy much anymore, and can withstand long periods of non-use. The mechanical and electronic components are durable and reliable so despite what your proclivities are, there really is nothing to worry about.