I'll be shopping for a new (or new-ish) truck shortly for pulling a medium size trailer or 5th wheel. It seems like the vast majority of 3/4 and 1 ton trucks around here are 4WD, with jut a few 2WD...
I was trying to back my 5th wheel up a slight hill, dirt with small rocks, and my tires spun. After a couple tries, I put it in 4WD and backed right up. I probably could have worked it out in 2WD. More likely, when I'm not hooked up I'm often on dirt roads and use the 4WD. I'm in Utah, we get snow. Lots of dirt roads.
So, it comes back what your use case is. It does kind of stink to give up the payload for the 4wd, but I gave some up for the diesel too. Mmm... In Utah, gotta have the 4wd.