I had a 2008 5.4L F250 (heavy, crew cab 4x4 XLT) and I went from 3.73 to 4.30 and felt it made a big difference.
Having said that, in my perception, that heavy of a chassis calls for V10 or diesel power. 300hp/365tq in a 3400lb sports car is one thing, 300hp/365tq motivating a 7500lb truck is another entirely.
Very subjecrive at the end of the day; one man's underpowered is another's man's more-than-plenty.
Bottom line, been there/done that, deep gears are a big aid in a borderline underpowered scenario.
Gearing is funny; there's a such thing as "too much of a good thing." I have a V8 Volvo XC90, 4500lb, and with 311hp/329tq and a 4.14 1st gear it's nervous & jumpy off the line.
Lots of gray in the world of the "right" gearing for the "right" weight & the "right" situation.