Had an '05 6.0 PSD F250. Changed out the EGR and oil cooler (I learned the hard way about the Ford Gold coolant, see below), then the FICM went bad. Other than that, it ran great. Would still have it but I sold the 5ver it was towing, and I downsized both the trailer and my truck. Got an outstanding trade-in, more than I figured. There are three things a 6.0 owner needs to do, and his truck should be fine, unless he is just plain unlucky.
1) Get that crappy Ford Gold coolant out of there, flush it well, and install some type of ELC coolant. This is a major cause of EGR failure. The FG coolant contains silica (sand). Once it gets real hot, just once, it gums up the oil cooler, and things go downhill from there.
2) Don't let your oil changes go past 6000 miles. I always sent an oil sample to Blackstone Labs after an oil change. They always came back excellent, except for the one time I let it slip to around 7200 miles. That sample came back with too much metal in it. Subsequent samples were back to excellent.
3: DON'T CHIP IT !!! The engine was designed by IH for 265 HP, Ford upped it quite a bit, it can't handle much more without bad things happening.
I would also advise installing an EGT gauge. About $100 (you can spend more if you want to...) and 30 minutes work.