Hum, the F250 is a really nice truck but felt under powered to me with the 3.73 axles. Truck itself was very nice but very expensive at about $50,000 MSRP with little rebates.
It could get around the payload limitations of my F150 but I don't know if I could get use to the lower power output after being spoiled with the power of the 5.0L and the lighter truck.
I had always thought about getting the Ram CC 2500 6.4L 4WD truck when I was finished with this. Mainly because I was told mileage was much better since I use my truck to commute to work and the 6.4L offers quite a bit more power and is lighter. On top of that, I think it's even cheaper.
I really liked the F250 but it needs more low end power like from the V10 they stopped offering. BUT I guess the 4.30 gears would help but then it will likely drink so much gas, couldn't be used for commuting to far.
Here's my review on the 2014 6.2L F250.