CEL = Check Engine Light. Its a fault indicator that something in the emissions system is faulting. There are dozens of things that can trigger a CEL, some single incidents but mostly multiple readings over test cycles or starting cycles. Even when you get the code(s) you may still have to dig deeper. For example a code may specify an issue with an O2 sensor. But the root cause may be something upstream.
The trouble with having the code read by a parts store is that they will always try to sell you parts based on "their interpretation" of the code. In the case of cylinder misfires though they are probably right. But still, check the plug. BTW, how old are the plugs? Next swap the coil with another, at least I know you can do this on GMs. At 120k if the plugs have not been changed I would do the entire set.