Crossed over to Diesel

I have a 2005 F250 6.0 as well, and have become expert on these beasts. There is an issue with the stock fuel pressure regulator spring and Ford put out an update in 2009 or so. It's mandatory that you get the fuel pressure tested at a dealer, and have the kit installed - it's under $50 for the kit and takes about a half hour. The fuel pressure will be around 60 psi at idle with the updated spring. Other than that, monitor the oil and water temps with a Scangauge II or equivalent OBDII data reader, change the oil every 5K miles and the fuel filters (two of them) every 15K miles and don't tune it. Last thing - use the Scangauge to monitor the FICM voltage - if it drops below 46 volts at any time, it is failing and will take out injectors. The good thing about this engine is that these little issues are well know and well documented, and have proven fixes readily available.

Brian