There are tuners designed to be used with DPF intact and tuners designed to work only with the DPF removed and generally say something like "for off highway race use only". Any removal of the DPF system could pose a big problem if you have emissions testing in your area. I spend a good bit of time on the Dodge Cummins Diesel forum. It looks to me like a high percentage of the folks reporting big problems are driving trucks with tuners. I realize many people that tune their trucks drive them hard. I know people that have tuned their trucks with no problems for many miles (no emissions testing here), but I think the best chance for getting the truck to go high miles with minimal issues is keeping it stock. Good luck. Keith