My 2019 F450 was a capable platform, but the aluminum bed is a weak spot. Not a show stopper but if your planning on a heavy camper, that bed will show a few bent or sagging spots if you ever drive on crappy roads with lots of transitions.
I loved my F450 as a stable well mannered hauler. Now that I have a Ram 5500, its very stable and carries the load even better.
Both had stiff tires and suspension that would let you know every big bump you hit.
I pay quite a bit more for the 5500 insurance. My F450 was weighing 15600 at the last weight. Full water and loaded for travel. Well over legal. My 5500 weighed 16700. 2800 lbs below payload.
The bed is longer and supports more of the camper. Lots more storage both below and above the bed is possible. That alone makes it a very positive choice for me.
Now add new suspension and its even better.