You need a few more trips under your belt to see if it is related to what you are towing or just road/wind/temperature/fill conditions.
A couple of friends of ours have 5th wheels, we have a regular trailer. All are similar weight/length, tow vehicles are from all 3, ford, dodge, gm. All are diesels
When we travel together and stop for fuel, seems like all of us are taking the same amount of fuel +/- a few gallons with typical fills in the 30 gallon range.
And it varies as to who has used the most (or least) fuel.