is 2500 +/- each way road trip pratical in 10 days?

Every two years we head down to Dallas from Connecticut, wife always wants to make it in 3 days or less. Of course, she's resting while I drive. When I get there, all I want to do for the next 24 hours is rest/sleep and stretch my legs to get rid of the aches. I'd rather take the extra time and enjoy the scenery (and have the wife drive if she is so impatient to see the kids).
Plan on extra time looking for gas stations that are open in the wee hours of the night.