Is there a difference between 3.73 locking rear axle & 4.30?

I currently tow approximately 8500 lbs with a Tundra. The Tundra has 5.7L V8 381 hp/401 lb-ft with a 4.300 rear diff. Looking at purchasing a Ford F-250 gas 4X2 with a 3.73 rear locking axle. Will I g...