How much the thrust angle of the driveline is impacted, depends on the length of the driveshaft from the pinion shaft to the carrier bearing and/or the tailshaft of the transmission (if there is no carrier, intermediate) bearing.
IOW the shorter the distance the more critical the alignment becomes.
Dropping the rear height 2" with a long driveshaft may not impact the U joints at all, whereas a short driveshaft length will. Why, when I lifted my truck 4" fron and back, I rotated the differentials front and rear with degree shims to replicate the angle the OEM had the driveshafts at. I machined my own shims in the shop from die steel and that was 90K miles ago and I have had no U joint issues to date. I did can the OEM U joints almost right away and replaced them with Super U's that are greasable, unlike the factory sealed for life junk.