I just replaced my 2001 7.3 powerstroke with a new 2016 6.7 powerstroke 4X4 I know the 6.7 won't get the mileage that my old truck got but once it's broke in what kind of mileage are you 6.7 owners ...
I wouldn't assume it's mileage will be worse. Assuming you drive the same.
My 2015 Duramax 6.6 gets noticeably better unloaded mileage in town and on the highway than my 04.5 did. about 10 percent better on the highway when traveling the same route.
Towing, didn't change enough to notice. That wind drag dominates.