I ran the Vision/Toyo setup from 2006 to 2013 with about 60,0000 miles ...... camper loaded. No catastrophes, blowouts or a single flat tire during that time frame. I really enjoyed the stress free relationship that I enjoyed with that set-up.
Prior to the 19.5s, I was always a bit freaked out about the prospect of a blowout with the camper. I don't feel nearly as vulnerable with the fiver because in the event of tire failure, I feel I can safely stop the trailer.
Once I went to a fiver I sold the Vision rims (tires were worn out) and went back to a stock 3750 E rated tire. The beauty of the stock set up is I can air down in the sand. I had to get towed out of sand 3 or 4 times with the pizza cutters and really couldn't stand the ride when the camper was off or trailer disconnected.