I believe brakes are the same, as mentioned coils vs leafs on the rear, the rear air leveling suspension can be had on both but are different systems likely due to the coil vs leaf setup. And also as mentioned previously the 3500 you can get the Aisin trans. When I bought my 17 3500 SRW you had no choice in axle ratio only the DRW's had that option so same as the 2500 but that may or may not have changed since then. The payload difference, gvwr and gcwr whether real or just on paper not sure but since they do have different suspensions unlike earlier years it may very well be different. I know that when I bought my 17 the difference between the longbed, cc, 2500 and the longbed, cc, 3500 srw was literally about $400. And for that amount I went with the 3500 especially since the 2500 payload numbers were around 2000lbs less and with my use I was close to the max on the 2500 so for $400 went tothe 3500 and peace of mind.