From a powertrain standpoint, my '05 3500 has been fine. Everything around the engine, not so much. Most annoying and frequent issue, water leaks, yes water leaks. Have occurred through the clearance lamps, and have had water running down the inside of both A posts and onto the floor by the kick panels. Have replaced and sealed clearance lamps, replaced door gaskets and still it happens, parked or running down the road. I have given up and just park under it under a tree in rainy weather. Seems to help...........